Abstract
The readily available, heterogeneous, and inexpensive catalyst
nickel-on-charcoal (Ni/C) can be used to mediate couplings between
vinyl alanes and benzylic chlorides under very mild conditions and
in good yields. Although such allylated aromatics are themselves
important compounds, as demonstrated in this work, their syntheses
under the ‘green chemistry’ conditions used can smoothly
arrive at precursors to valued quinone natural products, such as
the nutraceutical coenzyme Q10 .
Key words
heterogeneous catalysis - nickel-on-charcoal - cross-couplings - allylated aromatics
- coenzyme Q10
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